SmartGym vs Isomorphic Labs
Side-by-side comparison of features, pricing, and ratings
At a glance
| Dimension | SmartGym | Isomorphic Labs |
|---|---|---|
| Target Audience | Apple device users (strength training) | Pharma companies (drug discovery) |
| Pricing | Freemium + $9.99/mo subscription | Contact for pricing (pharma partnerships) |
| AI Use Case | Personalized workout plans, periodization, exercise swapping | Protein-ligand prediction, novel molecule design |
| Platform | iOS / iPadOS / watchOS / macOS | N/A (research collaborations) |
| Key Integration | Strava (added in v7.8) | Partnerships with Novartis & Johnson & Johnson |
| Latest News | v7.10: Custom HR zones, custom exercises in Smart Trainer | Series B funding (Feb 2026), $600M investment (2025) |
These tools serve entirely different markets—SmartGym for individual Apple fitness users, Isomorphic Labs for big pharma AI drug discovery. Your choice comes down to whether you need a personal AI coach for strength training on Apple devices (go SmartGym) or want a high‑investment partnership for AI‑driven therapeutic design (go Isomorphic Labs). There is no overlap in use case.
AI-powered workout app for Apple that builds and adapts strength programs around your goals, equipment, and schedule.
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What real users say: SmartGym vs Isomorphic Labs
Not marketing copy and not our opinion — a structured sweep of public discussion (reviews, forums, communities and video comments), showing what people praise and what they complain about for each tool.
SmartGym
56 mentions across 3 sources · 100% positive
Product Hunt, App Store, Bluesky
What users praise
- • Excellent Apple Watch integration with full offline independence
- • AI Smart Trainer uses periodization to auto-adjust weights and reps
- • Over 730 animated exercises with step-by-step instructions
- • 130+ professionally designed, ready-to-use workouts
What frustrates them
- • Only available on Apple devices, no Android or web
- • Mac subscription popup lacks close button in reported bug
- • Full features require a subscription after 7-day trial
- • Limited negative feedback sample may hide real issues
Researched Jul 3, 2026
Isomorphic Labs
46 mentions across 3 sources · 73% positive
Hacker News, YouTube, Lemmy
What users praise
- • Backed by DeepMind's AlphaFold legacy and Nobel-winning science.
- • Massive pharma partnerships: Novartis, J&J, Eli Lilly.
- • Drug Design Engine (July 2026) moves beyond structure prediction.
- • Generative AI for molecule design, simulating drug behavior.
What frustrates them
- • Not a self-serve tool; partnership-only model limits access.
- • CASP16 shows no clear advantage over older prediction methods.
- • Clinical outcomes unproven; no approved drugs yet.
- • Returns tied to performance milestones, uncertain timeline.
Researched Aug 26, 2026
Who should pick which
- Apple Watch fitness enthusiastPick: SmartGym
SmartGym is the only app here, designed for Apple devices with offline watch support, 730+ exercises, and AI periodization. Perfect for tracking strength training progress.
- Big pharma VP of R&DPick: Isomorphic Labs
Isomorphic Labs partners with Novartis and J&J for large‑scale AI drug discovery. Their Drug Design Engine leverages AlphaFold for predictive protein‑ligand modeling—ideal for accelerated lead optimization.
- Athlete wanting customizable AI coachingPick: SmartGym
SmartGym’s Smart Trainer adjusts weights and reps based on actual performance. Latest update adds custom exercises and heart‑rate zones for fine‑tuned training.
- Early‑stage biotech startupPick: Isomorphic Labs
If you seek a deep‑pocketed pharma partner with foundational AI (AlphaFold), Isomorphic Labs is the only option. Their collaboration model is built for long‑term drug development programs.
Frequently Asked Questions
SmartGym vs Isomorphic Labs: which should you choose?
These tools serve entirely different markets—SmartGym for individual Apple fitness users, Isomorphic Labs for big pharma AI drug discovery. Your choice comes down to whether you need a personal AI coach for strength training on Apple devices (go SmartGym) or want a high‑investment partnership for AI‑driven therapeutic design (go Isomorphic Labs). There is no overlap in use case.
Can I use SmartGym on Android?
No. SmartGym is exclusive to Apple devices: iPhone, iPad, Mac, and Apple Watch.
Does Isomorphic Labs offer a public API?
No. Isomorphic Labs works only through direct pharma partnerships with Novartis and Johnson & Johnson.
What does the SmartGym subscription cost?
SmartGym Premium costs $9.99/month or $49.99/year. A free tier exists with limited features.
How much does Isomorphic Labs charge?
Pricing is not public; it is negotiated per partnership, likely involving multi‑million dollar commitments.
Does SmartGym integrate with Strava?
Yes, Strava sync was added in SmartGym v7.8 (Feb 2026).
What is the latest news about Isomorphic Labs?
Isomorphic Labs closed a Series B in February 2026, after a $600M external investment round in 2025. It also established US operations and appointed a CMO.
Can I create custom workouts in SmartGym?
Yes. You can create routines from scratch or paste text using Apple Intelligence. The latest v7.10 also adds custom exercises to the Smart Trainer.
Is SmartGym good for beginners?
Yes, it includes 730+ animated exercises with step‑by‑step instructions and automatic progression via the Smart Trainer.
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Last reviewed: July 3, 2026